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From the 2026 2nd Quarter Pressure

Elaine M. Silverman, MD, MPH
Suwen Wu, MS
Jay C. Buckey, MD

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Multicenter Registry Update

The Multicenter Registry for Hyperbaric Oxygen Therapy was well-represented at the 2026 AsMA-UHMS Annual Scientific Meeting in Denver

A poster presented by Suwen Wu, MS, gave a comprehensive summary of the registry’s 2025 activity. Here are some of the highlights:

Registry Statistics as of December 31, 2025:

  • 33 centers were actively contributing data, with additional centers in the onboarding process.
  • The registry contained 15,226 patient records in total.
  • A total of 2,330 records were newly submitted and processed in 2025
  • The three most common UHMS indications were delayed radiation injury (N=826; 32.69%), compromised grafts and flaps (N=359; 14.21%), and carbon monoxide poisoning (N=310; 12.27%).
  • Among non-UHMS indications with valid coding (N=125), the most common were COVID-19 (N=21; 16.8%), other (N=46; 36.8%), and frostbite (N=12; 9.6%).
  • Pre- to post-treatment outcome changes to post-treatment outcome changes were observed across several common indications, consistent with prior years.

Figure 1:
2025 UHMS Indications (Cases) 
Referred or Treated

Picture1

Figure 2:
2025 Non-UHMS Indications (Cases)
Referred or Treated
Picture2

Figure 3:
Hematuria Severity (All Centers)
Pre vs Post (lower scores = improvement)

Picture3

Other presentations of research involving Registry data included:

“Hyperbaric Oxygen for Brain Radionecrosis: Outcomes from the Multicenter Registry and Comparison to Bevacizumab,” Elaine Silverman, MD

“Hyperbaric Oxygen Therapy for Sudden Sensorineural Hearing Loss,” Christopher Niemczak. AuD, PhD

“Outcome of Patients Treated for Radiation Injuries at 2.0 ATA versus 2.4 ATA, Dartmouth Registry,” Lindell Weaver, MD

“HBOT Protocols for Iatrogenic Cerebral Gas Embolism: ‘one and done’ or ‘to complete’,” Dr. Robert Weenink

Panel Debate on the Importance of Registries, Jay Buckey, MD, Helen Gelly, MD, and Caroline Fife, MD

Recent Publications:

Booher AG, McGonagle KE, Peacock JL, Silverman EM, Hannigan PM, Bornt LC, Bihrle W 3rd, Buckey JC, Moses RA. Factors Associated with Hematuria Resolution and Hematuria Admissions After Hyperbaric Oxygen Therapy for Chronic Radiation Cystitis. Urol Pract. 2026 Jun 16:101097UPJ0000000000001041. doi:10.1097/UPJ.0000000000001041. Epub ahead of print. PMID: 42302178.

Ganga K, Niemczak C, Buckey J. In Reference to Adjunctive Hyperbaric Oxygen Therapy or Intratympanic Steroids in Sudden Sensorineural Hearing Loss? Laryngoscope. 2026 Jun 7. doi: 10.1002/lary.70670. Epub ahead of print. PMID: 42252517.

Papers out for Review:

Angus J. Hayes, MD, Dip DHM, Jay C. Buckey, MD, Rachel A. Moses, MD, MPH, Isobel Savulescu, MD, Janet L. Peacock, PhD, Sabiqul Hoque, MBBS, Jan Lehm, MD
for the Multicenter Registry for Hyperbaric Oxygen Treatment Consortium, Hyperbaric Oxygen Improves Radiation Proctitis Patient-Reported Outcomes.

Christopher E. Niemczak, Au.D., Ph.D., Kiran Ganga, M.S., Suwen Wu, M.S., Samantha M.Leigh, B.S., Elaine M. Silverman, M.D., Pamela M. Hannigan, R.N., Jay C. Buckey, M.D. for the Multicenter Registry for Hyperbaric Oxygen Treatment. Hyperbaric Oxygen Therapy for Idiopathic Sudden Sensorineural Hearing Loss: Registry‑Based Outcomes