Description

Asserson DB, Becker DB, Alleman TL, Kruchevsky D. Hyperbaric Oxygen as a Treatment Modality for

Radiation-Induced Breast Calcinosis. Undersea Hyperb Med. 2026 Third Quarter; 53(3):467-470.

Introduction: Breast calcinosis is a rare late complication of radiation therapy that can present years

after treatment and pose significant reconstructive challenges. Management of radiation-induced breast

calcinosis requires an approach to address both tissue damage and impaired wound healing.

Case Report: We present a case of a 59-year-old female who developed breast calcinosis more than a

decade following radiation. Our multistep treatment plan, which has not been previously published,

involved hyperbaric oxygen (HBO2) treatment, surgical excision, negative pressure wound therapy, and

additional HBO2 treatment. As a result, the patient’s wound decreased to 95% of its size in less than two

months.

Discussion: This case highlights the potential utility of a staged multidisciplinary approach for managing

radiation-induced breast calcinosis and supports further investigation of HBO2 treatment as an adjunct to

optimize wound healing in these complex patients.

Keywords: breast cancer; dystrophic calcifications; hyperbaric oxygen; radiation therapy